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Human Physiology
Author(s) -
John R. Brobeck
Publication year - 2003
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1111/j.1469-7793.2003.tb00606.x
Subject(s) - citation , computer science , information retrieval , world wide web
After Ethics Committee approval consenting women were scanned at term, 6 weeks and, if possible, 6 months after delivery. Control women had scans a month apart. All measurements were obtained using a 1.5 T EclipseTM MR scanner (Philips Medical Systems Inc., Cleveland, Ohio, USA). P MR spectra (TR = 10 s, 64 signal averages) were localised on a 70 w 70 w 70 mm voxel in the brain using an ISIS sequence. The MR spectra were analysed by an observer blinded to the clinical status of the subjects using prior knowledge (Hamilton et al. 2002) in the AMARES algorithm included in the MRUI software program. The peak areas of phosphomonoester (PME), inorganic phosphate (Pi), phosphodiester (PDE), phosphocreatine (PCr), and nucleoside triphosphate (g, a and bNTP) resonances were calculated as a percentage of the total peak areas. Further the intracellular pH was calculated using: