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Human Physiology
Author(s) -
K. George,
S. Myerson,
K. Birch,
M. World,
D. Pennell,
Hugh Y. Elder,
Sherine Tavadia,
Douglas L. Bovell
Publication year - 2002
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1111/j.1469-7793.2002.tb00394.x
Subject(s) - citation , computer science , information retrieval , world wide web
It is well known that periods of contractile activity result in adaptations to muscle structure and function. Clearly, this type of muscle remodelling must involve changes in the rate of muscle protein turnover. One of the major pathways for muscle protein turnover is the calpain proteolytic system (Goll et al. 1998), which comprises several calpain isoenzymes and their specific endogenous inhibitor calpastatin. The calpain system is believed to be responsible for cytoskeletal remodelling in muscle fibres and is also associated with myoblast differentiation and fusion, fibre hypertrophy and growth. However, in human skeletal muscle little is known about the effects of exercise on the calpain system, and how this relates to changes in muscle composition and function.