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Sex differences in the acetylcholine receptor kinetics of postnatal and denervated rat muscle
Author(s) -
Villarroel Alfredo
Publication year - 2001
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1111/j.1469-7793.2001.0175g.x
Subject(s) - acetylcholine receptor , acetylcholine , medicine , receptor , endocrinology , kinetics , chemistry , homogeneous , biology , anatomy , biophysics , physics , quantum mechanics , thermodynamics
1 Single‐channel recording from visualised endplates in freshly dissociated muscles from postnatal and denervated rat muscle revealed the presence of a low conductance, fetal type of acetylcholine receptor. 2 Kinetic analysis showed a main component in the burst durations with a mean of 10.8 ± 2.7 ms ( n = 29 ). Receptors from female rats had an additional 27.3 ± 5.5 ms ( n = 5 ) kinetic component which was found in one‐third of the 15 female endplates. 3 Recordings from male and female denervated muscles gave more homogeneous kinetics with single time constants of 7.2 ± 1.3 and 7.4 ± 1.3 ms, respectively. 4 It is concluded that the acetylcholine receptor channels present during early development are different from those of denervated muscle.