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Responses of single‐unit carotid body chemoreceptors in adult rats
Author(s) -
Vidruk Edward H.,
Olson E. Burt,
Ling Liming,
Mitchell Gordon S.
Publication year - 2001
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1111/j.1469-7793.2001.0165j.x
Subject(s) - carotid body , chemoreceptor , pco2 , medicine , chemistry , anesthesia , hypoxia (environmental) , oxygen , oxygenation , endocrinology , electrophysiology , receptor , organic chemistry
1 Our goal was to describe the in situ responses in rats of single‐unit carotid body chemoreceptors to changes in arterial P O2 and P CO2 . We identified single‐unit carotid chemoreceptor activity in male, adult Sprague‐Dawley rats by their rapid responses to i.v. NaCN (20 μg) and transient (10 s) asphyxia. 2 Single‐unit chemoreceptor responses to isocapnic changes in oxygenation within the arterial oxygen pressure range 34‐114 mmHg were described by the power function: f dis = 74010( P a,O 2) −2.5 ; ( r 2 = 0.6 ), where f dis is the discharge frequency (spikes s −1 ), P a,O 2is the arterial oxygen partial pressure (mmHg) and r 2 is the correlation coefficient. 3 The responses to iso‐oxic changes in CO 2 , assumed to be linear, had a slope of 0.089 spikes s −1 (mmHg P a,CO2 ) −1 ( r 2 = 0.7 ). 4 We conclude that carotid body chemoreceptors in adult rats have responses to changes in P a,O 2and P a,CO2 similar to those of other species.