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Receptors, gephyrin and gephyrin‐associated proteins: novel insights into the assembly of inhibitory postsynaptic membrane specializations
Author(s) -
Kneussel Matthias,
Betz Heinrich
Publication year - 2000
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1111/j.1469-7793.2000.t01-4-00001.x
Subject(s) - gephyrin , postsynaptic potential , inhibitory postsynaptic potential , postsynaptic density , neurotransmitter receptor , microbiology and biotechnology , biology , neuroscience , receptor , excitatory postsynaptic potential , glycine receptor , biochemistry , glycine , amino acid
The synaptic localization of ion channel receptors is essential for efficient synaptic trans‐mission and the precise regulation of diverse neuronal functions, such as signal integration and synaptic plasticity. Emerging evidence points to an important role of cytoskeleton‐associated proteins that assemble receptors and components of the subsynaptic machinery at postsynaptic membrane specializations. This article reviews interactions of inhibitory postsynaptic neurotransmitter receptors with the receptor anchoring protein gephyrin and intracellular components involved in downstream signalling and/or control of signal transduction processes. The presently available data suggest a central synaptic organizer function for gephyrin in inhibitory postsynaptic membrane assembly and stabilization.