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The actin cytoskeleton in store‐mediated calcium entry
Author(s) -
Rosado Juan A.,
Sage Stewart O.
Publication year - 2000
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1111/j.1469-7793.2000.t01-2-00221.x
Subject(s) - endoplasmic reticulum , microbiology and biotechnology , cytoskeleton , secretion , actin cytoskeleton , actin , calcium signaling , stim1 , gtpase , biology , chemistry , cell , signal transduction , biochemistry
Store‐mediated Ca 2+ entry is the main pathway for Ca 2+ influx in platelets and many other cells. Several hypotheses have considered both direct and indirect coupling mechanisms between the endoplasmic reticulum and the plasma membrane. Here we pay particular attention to new insights into the regulation of store‐mediated Ca 2+ entry: the role of the cytoskeleton in a secretion‐like coupling model. In this model, Ca 2+ entry may be mediated by a reversible trafficking and coupling of the endoplasmic reticulum with the plasma membrane, that shows close parallels to the events mediating secretion. As with secretion, the actin cytoskeleton plays an inhibitory role in the activation of Ca 2+ entry by preventing the approach and coupling of the endoplasmic reticulum with the plasma membrane, making cytoskeletal remodelling a key event in the activation of Ca 2+ entry. We also review recent advances investigating the regulation of store‐mediated Ca 2+ entry by small GTPases and phosphoinositides, which might be involved in the store‐mediated Ca 2+ entry pathway through roles in the remodelling of the cytoskeleton.