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Microvascular oxygen pressure in the pig intestine during haemorrhagic shock and resuscitation
Author(s) -
Sinaasappel M.,
Iterson M.,
Ince C.
Publication year - 1999
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1111/j.1469-7793.1999.245af.x
Subject(s) - university hospital , medicine , oxygen metabolism , emergency department , library science , chemistry , emergency medicine , oxygen , computer science , organic chemistry , psychiatry
1 The aim of this study was to investigate the relation between microvascular and venous oxygen pressures during haemorrhagic shock and resuscitation in the pig intestine. To this end microvascular P O 2(μ P O 2) was measured by quenching of Pd‐porphyrin phosphorescence by oxygen and validated for the intestines. In addition, mesenteric venous blood gasses, blood flow, ilial CO 2 production and global haemodynamics were also measured. 2 In one group ( n = 11 ), moderate shock was induced by withdrawal of 40% of the circulating blood volume. Seven of these animals were resuscitated with a crystalloid solution and four with the withdrawn blood. In a second group of three animals, a more severe shock was induced by withdrawal of 50% of the circulating blood volume; these animals were not resuscitated. 3 Baseline mesenteric venous P O 2and μ P O 2values were similar (60 ± 9 and 60 ± 11 mmHg, respectively). During moderate shock, μ P O 2dropped significantly below mesenteric venous P O 2(26 ± 10 versus 35 ± 8 mmHg). After resuscitation with crystalloid solution, μ P O 2and mesenteric venous P O 2rose to 44 ± 9 and 44 ± 6 mmHg, respectively. In the group that received the withdrawn blood, values were 41 ± 9 and 53 ± 12 mmHg, respectively. Severe shock resulted in a drop in the mesenteric venous P O 2( n = 3 ) to a value similar to that seen in the moderate shock group, but the gut μ P O 2dropped to a much lower value than that of the moderate shock group (15 ± 5 versus 26 ± 10 mmHg). 4 The results indicate that the oxygenation of the microcirculation of the gut can become lower than the venous P O 2under conditions of haemorrhagic shock.