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The effects of flow on the transport of potassium ions through the walls of single perfused frog mesenteric capillaries
Author(s) -
Kajimura M.,
Head S. D.,
Michel C. C.
Publication year - 1998
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1111/j.1469-7793.1998.707bg.x
Subject(s) - potassium , chemistry , biophysics , anatomy , flow (mathematics) , mechanics , biology , physics , organic chemistry
1 We have investigated the effects of varying flow velocity upon permeability to potassium ions ( P K ) of single perfused mesenteric microvessels in pithed frogs. 2 PK was estimated using a development of the single bolus microperfusion technique at chosen flow velocities ( U ) in the range of 150–7000 μ m s −1 . 3 In thirty‐seven out of forty‐three vessels, there was a strong positive correlation between P K and U. Average values (median) for P K (μ m s −1 ) were related to U (μ m s −1 ) by the expression: P K = 0.0043 U + 4.05 ( n = 43 ). 4 The correlation between P K and U was independent of microvascular pressure (and hence fluid filtration) over the range of 5–70 cmH 2 O. 5 The correlation between P K and U was independent of the potassium concentration in the bolus over the range of 2–40 mmol l −1 and of the direction of the potassium flux through the capillary walls.