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Structure and function of voltage‐gated sodium channels
Author(s) -
Marban Eduardo,
Yamagishi Toshio,
Tomaselli Gordon F.
Publication year - 1998
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1111/j.1469-7793.1998.647bp.x
Subject(s) - sodium channel , gating , sodium , biophysics , chemistry , depolarization , ion channel , phosphorylation , biochemistry , biology , receptor , organic chemistry
1 Sodium channels mediate fast depolarization and conduct electrical impulses throughout nerve, muscle and heart. This paper reviews the links between sodium channel structure and function. 2 Sodium channels have a modular architecture, with distinct regions for the pore and the gates. The separation is far from absolute, however, with extensive interaction among the various parts of the channel. 3 At a molecular level, sodium channels are not static: they move extensively in the course of gating and ion translocation. 4 Sodium channels bind local anaesthetics and various toxins. In some cases, the relevant sites have been partially identified. 5 Sodium channels are subject to regulation at the levels of transcription, subunit interaction and post‐translational modification (notably glycosylation and phosphorylation).