Premium
Vasopressin, angiotensin II and renal responses during water immersion in hydrated humans
Author(s) -
Hammerum Mette Schou,
Bie Peter,
Pump Bettina,
Johansen Lars Bo,
Christensen Niels Juel,
Norsk Peter
Publication year - 1998
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1111/j.1469-7793.1998.323bi.x
Subject(s) - vasopressin , natriuresis , endocrinology , medicine , angiotensin ii , chemistry , diuresis , renin–angiotensin system , sodium , plasma osmolality , excretion , kidney , blood pressure , organic chemistry
1 The hypothesis was tested that in hydrated humans the release of arginine vasopressin and angiotensin II is suppressed by water immersion (WI) and that this is a mechanism of the immersion‐induced diuresis and natriuresis. Seven male subjects on controlled sodium (65‐75 mmol per 24 h for 4 days) and water intake were studied. 2 Plasma vasopressin was promptly suppressed by WI, declining from 0·76 ± 0·13 to 0·23 ± 0·08 pg ml −1 ( P < 0 ·05), with a concomitant increase in renal water output ( C H2O ) from ‐0·4 ± 0·2 to 4·4 ± 0·7 ml min −1 ( P < 0 ·05). Subsequently, C H2O returned to the level of control, whereas plasma vasopressin remained suppressed. Plasma osmolality gradually increased from 285 ± 1 to 289 ± 1 mosmol kg −1 ( P < 0 ·05). WI caused a 9‐fold increase in renal sodium excretion. Plasma angiotensin II decreased from 27·1 ± 5·3 to 4·3 ± 0·7 pg ml −1 ( P < 0 ·05), and the intraindividual correlation coefficients between sodium excretion rates and angiotensin II concentrations varied between 0·73 and 0·96 ( P < 0 ·002). 3 The data demonstrate that plasma vasopressin and angiotensin II concentrations decrease during WI in hydrated humans, concomitantly with initial increases in C H2O and sodium excretion. Therefore, vasopressin could constitute a mediator of C H2O and angiotensin II of the natriuresis of WI. The subsequent return of C H2O to the level of control is, however, also caused by other factors.