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Metabotropic synaptic regulation of intrinsic response properties of turtle spinal motoneurones
Author(s) -
DelgadoLezama Rodolfo,
Perrier JeanFrancois,
Nedergaard Steen,
Svirskis Gytis,
Hounsgaard Jørn
Publication year - 1997
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1111/j.1469-7793.1997.097bf.x
Subject(s) - neuroscience , metabotropic glutamate receptor , ionotropic effect , glycine receptor , neurotransmission , chemistry , glutamatergic , metabotropic receptor , excitatory postsynaptic potential , biology , glutamate receptor , inhibitory postsynaptic potential , receptor , glycine , biochemistry , amino acid
1 The effect of a brief train of electric stimuli in the dorsolateral funiculus on the intrinsic response properties of turtle motoneurones was investigated in transverse sections of the spinal cord in vitro.2 Even when glutamatergic, GABAergic and glycinergic ionotropic synaptic transmission was blocked by antagonists of AMPA, NMDA, glycine and GABA receptors, dorsolateral funiculus (DLF) stimulation induced a facilitation of plateau potentials during current clamp and the underlying inward current in voltage clamp. This facilitation lasted more than 10 s. 3 The plateau potential and the facilitation by DLF stimulation was absent in the presence of 10 μ m nifedipine. The DLF‐induced facilitation was reduced by antagonists of 5‐HT 1 a , group 1 metabotropic glutamate receptors and muscarine receptors. 4 These findings suggest that the intrinsic properties of spinal motoneurones are dynamically regulated by afferent synaptic activity. These afferents can be of spinal and extraspinal origin. Continuous regulation of intrinsic response properties could be a mechanism for motor flexibility.