Photodynamic triggering of calcium oscillation in the isolated rat pancreatic acini | Zendy

Cui Zong Jie | Zendy; Kanno Tomio | Zendy

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Photodynamic triggering of calcium oscillation in the isolated rat pancreatic acini

Author(s) -

Cui Zong Jie,

Kanno Tomio

Publication year - 1997

Publication title -

the journal of physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.802

H-Index - 240

eISSN - 1469-7793

pISSN - 0022-3751

DOI - 10.1111/j.1469-7793.1997.047bf.x

Subject(s) - calcium , chemistry , oscillation (cell signaling) , biophysics , biology , medicine , biochemistry

1 Photodynamic agents, due to their photon‐dependent selective activation, can selectively activate a number of physiological processes and may directly modulate signal transduction in a number of cells including pancreatic acinar cells. 2 Activation of the photodynamic agent sulphonated aluminium phthalocyanine (SALPC) triggered recurrent cytosolic calcium ([Ca 2+ ] i ) spiking in pancreatic acinar cells. 3 The photodynamically triggered calcium spiking could be blocked by phosphatidylinositol‐specific phospholipase C (PI‐PLC) inhibitor U73122, but not by phosphatidylcholine‐specific phospholipase C inhibitor D609. 4 Removal of extracellular Ca 2+ abolished spiking, as did 2‐aminoethoxydiphenylborate (2‐APB), an inhibitory modulator of IP 3 ‐mediated Ca 2+ release from intracellular stores. 5 These data suggest that SALPC photodynamic action may permanently fix PI‐PLC in an active conformation, and this produced recurrent [Ca 2+ ] i spiking.

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