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Autism and the Immune System
Author(s) -
Gent Tiejo,
Heijnen Cobi J.,
Treffers Philip D. A.
Publication year - 1997
Publication title -
journal of child psychology and psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.652
H-Index - 211
eISSN - 1469-7610
pISSN - 0021-9630
DOI - 10.1111/j.1469-7610.1997.tb01518.x
Subject(s) - autism , psychology , developmental psychology , developmental disorder
As our knowledge of the interactions of the immune, nervous and endocrine systems progresses, complex links with the origin and course of psychopathology in childhood are revealed. In this article the neuroimmunological literature on autism is reviewed. Relevant aspects of immune functioning and the neuroendocrine‐immune network are described. We present the immunological findings in autistic patients within two related conceptual frameworks: a viral and an autoimmune hypothesis. Interpretation of data is hampered by conceptual and methodological differences between studies. Both the clinical significance of the immune changes and the causal connection between immune changes and psycho‐pathological phenomena in autism remain to he elucidated. Recommendations for further research are given.