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Pathogenesis of Tourette's Syndrome
Author(s) -
Leckman James F,
Peterson Bradley S.,
Anderson George M.,
Arnsten Amy F. T.,
Pauls David L.,
Cohen Donald J.
Publication year - 1997
Publication title -
journal of child psychology and psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.652
H-Index - 211
eISSN - 1469-7610
pISSN - 0021-9630
DOI - 10.1111/j.1469-7610.1997.tb01508.x
Subject(s) - tourette syndrome , neuroscience , psychology , context (archaeology) , basal ganglia , cognition , cognitive science , disease , psychiatry , medicine , biology , central nervous system , pathology , paleontology
This review presents a model of disease pathogenesis in the context of CNS development M begins with an exploration of the clinical features and natural history of Tourette's syndrome. This is followed by a consideration of the role of genetic and non gene tic factors. An effort is then made to review the anatomical organization of the basal ganglia and related cortical sites. These circuits are intimately involved in (he normal processing of sensorimotor, cognitive, and emotionally laden information. Evidence implicating these circuits in the pathobiology of Tourette's syndrome is then considered. The review closes with the prospects for advances in interdisciplinary research and therapeutics using this model as a guide.