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Methylphenidate and Cognitive Perseveration in Hyperactive Children
Author(s) -
Tannock Rosemary,
Schachar Russell
Publication year - 1992
Publication title -
journal of child psychology and psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.652
H-Index - 211
eISSN - 1469-7610
pISSN - 0021-9630
DOI - 10.1111/j.1469-7610.1992.tb00940.x
Subject(s) - perseveration , cognitive flexibility , wisconsin card sorting test , methylphenidate , psychology , cognition , placebo , impulsivity , attention deficit hyperactivity disorder , clinical psychology , developmental psychology , crossover study , psychiatry , audiology , medicine , neuropsychology , alternative medicine , pathology
Effects of methylphenidate on cognitive flexibility were investigated in 26 children with Attention Deficit Hyperactivity Disorder (ADHD), by assessing perseverative errors an the Wisconsin Card Sorting Test (WCST) and the emergence of clinical symptoms indicative of cognitive perseveration, A double‐blind, placebo‐control, randomized crossover design was used in which each child was assessed twice in each drug condition (placebo, 0.3 and 1.0 mg/kg) Results indicated that methylphenidate increased perseverative errors on the first assessment but decreased them fin for second; clinical symptoms of perseveration occurred at both assessments. Findings suggest that MPH may reduce cognitive flexibility temporarily in some ADHD children.