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G1 to S phase cell cycle transition in somatic and embryonic stem cells
Author(s) -
Neganova Irina,
Lako Majlinda
Publication year - 2008
Publication title -
journal of anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 118
eISSN - 1469-7580
pISSN - 0021-8782
DOI - 10.1111/j.1469-7580.2008.00931.x
Subject(s) - embryonic stem cell , microbiology and biotechnology , stem cell , cell cycle , somatic cell , biology , adult stem cell , retinoblastoma protein , cyclin , retinoblastoma , genetics , cell , gene
It is well known that G1 to S phase transition is tightly regulated by the expression and phosphorylation of a number of well‐characterized cyclins, cyclin‐dependent kinases and members of the retinoblastoma gene family. In this review we discuss the role of these components in regulation of G1 to S phase transition in somatic cells and human embryonic stem cells. Most importantly, we discuss some new tenable links between maintenance of pluripotency and cell cycle regulation in embryonic stem cells by describing the role that master transcription factors play in this process. Finally, the differences in cell cycle regulation between murine and human embryonic stem cells are highlighted, raising interesting questions regarding their biology and stages of embryonic development from which they have been derived.