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Contribution of endothelial cells to organogenesis: a modern reappraisal of an old Aristotelian concept
Author(s) -
Crivellato E.,
Nico B.,
Ribatti D.
Publication year - 2007
Publication title -
journal of anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 118
eISSN - 1469-7580
pISSN - 0021-8782
DOI - 10.1111/j.1469-7580.2007.00790.x
Subject(s) - organogenesis , biology , microbiology and biotechnology , endothelial stem cell , effector , neuroscience , genetics , gene , in vitro
It is well established that many tissue‐derived factors are involved in blood vessel formation, but evidence is now emerging that endothelial cells themselves represent a crucial source of instructive signals to non‐vascular tissue cells during organ development. Thus, endothelial cell signalling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodelling. This review article summarizes some of the recent advances in our understanding of the role of endothelial cells as effector cells in organ formation.