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Oscillations in Stroke Volume and Cardiac Output Arising from Oscillatory Ventilation in Humans
Author(s) -
Davies L. Ceri,
Francis D. P.,
Crisafulli A.,
Concu A.,
Coats Andrew J. S.,
Piepoli Massimo
Publication year - 2000
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1111/j.1469-445x.2000.02032.x
Subject(s) - impedance cardiography , stroke volume , tidal volume , ventilation (architecture) , periodic breathing , cardiac output , cardiology , medicine , respiratory minute volume , heart rate , respiratory rate , amplitude , anesthesia , hemodynamics , blood pressure , respiratory system , heart failure , physics , quantum mechanics , thermodynamics
Oscillations in the cardiovascular system have been observed in patients with periodic breathing. It is not clear whether these are driven by primary oscillations in the respiratory system or whether an intrinsic cardiovascular instability is required, as previous studies with subjects performing voluntary periodic breathing have failed to produce the cardiovascular oscillations. We investigated whether cardiovascular oscillations occurred in healthy controls performing voluntary periodic breathing. Six healthy subjects performed voluntary periodic breathing with guidance from a real‐time computer display. We measured ventilation, end‐tidal partial pressures of O 2 (PO2) and CO2 (PCO2), heart rate, blood pressure (BP), arterial oxygen saturation and stroke volume and cardiac output by transthoracic impedance cardiography. Fourier analysis was used to quantify the size and phase of the periodic breathing‐induced oscillations in these parameters. Periodic breathing (amplitude 30% of mean ventilation) induced oscillations in end‐tidal PO2 (amplitude 0.8 kPa), end‐tidal P CO2 (amplitude 0.3 kPa), R‐R interval (amplitude 32.6 ms), systolic BP (amplitude 3 mmHg), diastolic BP (amplitude 3 mmHg), stroke volume (amplitude 8.0 ml, mean 79.5 ml) and cardiac output (amplitude 0.6 1, mean 5.9 l min‐1). The oscillations in stroke volume and cardiac output were nearly in phase with ventilation, with their peaks occurring 5.6 and 6.1 s, respectively, after the peak in ventilation. An oscillatory ventilatory pattern entrains the cardiovascular system in healthy controls into fluctuations, not only in heart rate and BP, but also in stroke volume and cardiac output.