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Power Output of Fast and Slow Skeletal Muscles of MDX (Dystrophic) and Control Mice After Clenbuterol Treatment
Author(s) -
Lynch Gordon S.,
Hinkle Richard T.,
Faulkner John A.
Publication year - 2000
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1111/j.1469-445x.2000.02018.x
Subject(s) - clenbuterol , mdx mouse , duchenne muscular dystrophy , muscular dystrophy , endocrinology , medicine , skeletal muscle , extensor digitorum longus muscle , soleus muscle , chemistry , dystrophin
The mdx mouse is the most commonly used animal model for Duchenne muscular dystrophy. We tested the null hypothesis that 20 weeks of clenbuterol treatment (∼2 mg kg −1 day ‐1 ) of mdx and control mice would have no effect on the absolute and specific force ( P o , kN m −2 ) and absolute and normalised power output (W kg −1 ) of extensor digitorum longus (EDL) and soleus muscles. For mdx and control mice, clenbuterol treatment produced modest increases in the mass of the two muscles but did not increase absolute or specific force or normalised power output. For absolute power output, only the EDL muscles of mdx mice showed a difference following treatment, with the power output of treated mice being 118% that of the untreated mice. The modest effects of clenbuterol treatment on the dynamic properties of skeletal muscle provide little support for any improvement in muscle function for the dystrophic condition.