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Volumetric change of the lateral ventricles in the human brain following glucose loading
Author(s) -
Puri B. K.,
Lewis H. J.,
Saeed N.,
Davey N. J.
Publication year - 1999
Publication title -
experimental physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.925
H-Index - 101
eISSN - 1469-445X
pISSN - 0958-0670
DOI - 10.1111/j.1469-445x.1999.tb00085.x
Subject(s) - lateral ventricles , anatomy , human brain , neuroscience , medicine , cardiology , biology
SUMMARY Lateral ventricular volumes were monitored and quantified using accurately registered magnetic resonance images (MRIs) in six healthy individuals 30 min before and up to 4 h after ingestion of a glucose drink. The volume of the lateral ventricles increased by an average (± S.E.M.) of 2.4 ± 0.4 % as blood glucose levels rose from 4.8 ± 0.2 mmol l −1 to 8.4 ± 0.4 mmol l −1 . This was followed by a peak decrease of 5.99 ± 3.3 % below initial fasting volumes as blood glucose levels fell to 5.0 ± 0.3 mmol l −1 . We suggest that the secondary volume decrease demonstrates a homeostatic process of brain volume regulation for which the mechanism remains uncertain.