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Transforming Growth Factor β1‐509C/T and +869T/C Polymorphisms on the Risk of Upper Digestive Tract Cancer: A Meta‐Analysis Based on 10,917 Participants
Author(s) -
Zhang CaiFeng,
Wang ZhongWei,
Hou MengXia,
Li Kun,
Zhou Xiang,
Xia YongHua
Publication year - 2012
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.2012.00717.x
Subject(s) - digestive tract , meta analysis , biology , risk factor , genetics , cancer , medicine , oncology
Summary The aim of this study was to assess the relationships between transforming growth factor β1‐509C/T (rs1800469) and +869T/C (rs1800470) polymorphisms and the risk of upper digestive tract cancer (UDT cancer) by using a meta‐analysis. We interrogated the databases of Medline, Embase and Wanfang (Chinese literature database) (latest update; December 15, 2011). Odds ratios (OR) and corresponding 95% confidence intervals (95% CI) were used to assess the strength of the associations. In total, 20 case‐control studies were included in this meta‐analysis. Overall, both TGF β1‐509C /T and +869T/C polymorphisms were not associated with risk of UDT cancer [‐509C/T: OR (95%CI) = 1.10 (0.99–1.22) for TT vs. C carries, P heterogeneity = 0.10; +869T/C: OR (95%CI) = 1.04 (0.88–1.23) for CC vs. T carriers, P heterogeneity = 0.02]. Subgroup analyses indicated that the ‐509T allele was associated with increased risk of UDT cancer in population‐based studies (OR = 1.16 (1.04–1.31), P heterogeneity = 0.31 for TT vs. C carriers) and in small sample‐sized studies (OR = 1.45 (1.15–1.84), P heterogeneity = 0.56 TT vs. C carriers). All subgroup analyses for the TGF β1 +869T/C polymorphism indicated null association except for hepatocellular carcinoma. Interestingly, both the TGF β1‐ 509T allele and the +869C allele were associated with decreased risk of hepatocellular cancer based on limited original studies. This meta‐analysis indicated that TGF β1‐509C /T rather than +869T/C is a potential risk factor for UDT cancer.