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Association between Lipoprotein‐Associated Phospholipase A 2 Gene Polymorphism and Coronary Artery Disease in the Chinese Han Population
Author(s) -
Li Liyun,
Qi Liping,
Lv Naqiang,
Gao Qian,
Cheng Yanmei,
Wei Yingjie,
Ye Jue,
Yan Xiaowei,
Dang Aimin
Publication year - 2011
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.2011.00666.x
Subject(s) - medicine , coronary artery disease , lipoprotein associated phospholipase a2 , single nucleotide polymorphism , family history , genotype , body mass index , myocardial infarction , population , allele frequency , gastroenterology , allele , endocrinology , cholesterol , genetics , lipoprotein , biology , gene , environmental health
Summary The role of the lipoprotein‐associated phospholipase A 2 gene ( PLA2G7) in atherosclerosis remains controversial. We investigated the frequency of single‐nucleotide polymorphisms (SNPs) of PLA2G7 (rs16874954 and rs1051931) and their association with coronary artery disease (CAD) in a cohort of CAD patients ( n = 806) and age‐matched healthy controls ( n = 482) in the Chinese Han population. The VF and FF genotype of rs16874954 was significantly more frequent in the CAD patients (13.5%) than in the controls (9.3%, P = 0.024). The association remained after adjustment for age, gender, body mass index, smoking status, history of diabetes, positive family history of CAD, high‐density lipoprotein cholesterol, and triglyceride (OR = 1.922; 95% CI [1.146–3.224]; P = 0.013). There was no significant difference in the frequency of any genotype of rs1051931 between the two groups. However, the frequency of the allele V379 was significantly greater in CAD patients with a history of myocardial infarction (MI) than in those without a history of MI (18.7% and 14.8%, P = 0.038). We conclude that there is significant association between the rs16874954 mutation and CAD in the Chinese Han population. The expression of rs1051931 variant in CAD patients may entail increased risk of MI.