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Heritability of Serum Osteoprotegerin
Author(s) -
Kwan Johnny S. H.,
Xiao Sumei,
Bow Cora,
Cheung ChingLung,
Soong Cissy,
Lau Kam S.,
Sham Pak C.,
Kung Annie W. C.
Publication year - 2011
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.2011.00661.x
Subject(s) - osteoprotegerin , heritability , medicine , coronary artery disease , diabetes mellitus , disease , endocrinology , biomarker , physiology , biology , genetics , receptor , activator (genetics)
Summary Serum osteoprotegerin (OPG) level is a key biomarker for numerous traits of clinical importance like diabetes, coronary artery disease, blood pressure, lipid profile, and cancers, but its genetic basis remains poorly understood. We estimated the heritability ( h 2 ) of serum OPG level in 1442 southern Chinese subjects from 306 families. The h 2 for unadjusted OPG was 0.62 for females and 0.17 for males; and for age‐adjusted OPG, 0.75 for females and 0.37 for males. Adjustment for lifestyle factors including calcium and phytoestrogen intake, exercise, smoking, and alcohol consumption exerted only a modest effect on the h 2 . In conclusion, we confirmed that circulating OPG is a heritable trait and there is a significant difference in heritability between sexes.