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MQScore_SNP Software for Multipoint Parametric Linkage Analysis of Quantitative Traits in Large Pedigrees
Author(s) -
Axenovich Tatiana I.,
Aulchenko Yurii S.
Publication year - 2010
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.2010.00576.x
Subject(s) - pedigree chart , biology , linkage (software) , genetics , quantitative trait locus , genetic linkage , snp , software , snp array , population , computational biology , genotype , single nucleotide polymorphism , computer science , gene , medicine , operating system , environmental health
We describe software for multipoint parametric linkage analysis of quantitative traits using information about SNP genotypes. A mixed model of major gene and polygene inheritance is implemented in this software. Implementation of several algorithms to avoid computational underflow and decrease running time permits application of our software to the analysis of very large pedigrees collected in human genetically isolated populations. We tested our software by performing linkage analysis of adult height in a large pedigree from a Dutch isolated population. Three significant and four suggestive loci were identified with the help of our programs, whereas variance-component-based linkage analysis, which requires the pedigree fragmentation, demonstrated only three suggestive peaks. The software package MQScore_SNP is available at http://mga.bionet.nsc.ru/soft/index.html.