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Genome‐Wide Association Study Confirms SNPs in SNCA and the MAPT Region as Common Risk Factors for Parkinson Disease
Author(s) -
Edwards Todd L.,
Scott William K.,
Almonte Cherylyn,
Burt Amber,
Powell Eric H.,
Beecham Gary W.,
Wang Liyong,
Züchner Stephan,
Konidari Ioanna,
Wang Gaofeng,
Singer Carlos,
Nahab Fatta,
Scott Burton,
Stajich Jeffrey M.,
PericakVance Margaret,
Haines Jonathan,
Vance Jeffery M.,
Martin Eden R.
Publication year - 2010
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.2009.00560.x
Subject(s) - genome wide association study , single nucleotide polymorphism , odds ratio , genetic association , genetics , allele , biology , population , disease , gene , medicine , genotype , environmental health
Summary Parkinson disease (PD) is a chronic neurodegenerative disorder with a cumulative prevalence of greater than one per thousand. To date three independent genome‐wide association studies (GWAS) have investigated the genetic susceptibility to PD. These studies implicated several genes as PD risk loci with strong, but not genome‐wide significant, associations. In this study, we combined data from two previously published GWAS of Caucasian subjects with our GWAS of 604 cases and 619 controls for a joint analysis with a combined sample size of 1752 cases and 1745 controls. SNPs in SNCA (rs2736990, p‐value = 6.7 × 10 −8 ; genome‐wide adjusted p = 0.0109, odds ratio (OR) = 1.29 [95% CI: 1.17–1.42] G vs. A allele, population attributable risk percent (PAR%) = 12%) and the MAPT region (rs11012, p‐value = 5.6 × 10 −8 ; genome‐wide adjusted p = 0.0079, OR = 0.70 [95% CI: 0.62–0.79] T vs. C allele, PAR%= 8%) were genome‐wide significant. No other SNPs were genome‐wide significant in this analysis. This study confirms that SNCA and the MAPT region are major genes whose common variants are influencing risk of PD.