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Candidate Gene Association Study for Noise‐induced Hearing Loss in Two Independent Noise‐exposed Populations
Author(s) -
Konings A.,
Van Laer L.,
WiktorekSmagur A.,
Rajkowska E.,
Pawelczyk M.,
Carlsson P. I.,
Bondeson M. L.,
Dudarewicz A.,
Vandevelde A.,
Fransen E.,
Huyghe J.,
Borg E.,
SliwinskaKowalska M.,
Van Camp G.
Publication year - 2009
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.2008.00499.x
Subject(s) - noise induced hearing loss , single nucleotide polymorphism , snp , hearing loss , genetics , biology , candidate gene , noise (video) , odds ratio , noise exposure , audiology , gene , medicine , genotype , pathology , computer science , artificial intelligence , image (mathematics)
Summary Millions of people are daily exposed to high levels of noise. Consequently, noise‐induced hearing loss (NIHL) is one of the most important occupational health hazards worldwide. In this study, we performed an association study for NIHL based on a candidate gene approach. 644 Single Nucleotide Polymorphisms (SNPs) in 53 candidate genes were analyzed in two independent NIHL sample sets, a Swedish set and part of a Polish set. Eight SNPs with promising results were selected and analysed in the remaining part of the Polish samples. One SNP in PCDH15 (rs7095441), resulted in significant associations in both sample sets while two SNPs in MYH14 (rs667907 and rs588035), resulted in significant associations in the Polish sample set and significant interactions with noise exposure level in the Swedish sample set. Calculation of odds ratios revealed a significant association of rs588035 with NIHL in the Swedish high noise exposure level group. Our studies suggest that PCDH15 and MYH14 may be NIHL susceptibility genes, but further replication in independent sample sets is mandatory.