Premium
Apolipoprotein E genotype ε4/ε2 in the STANISLAS Cohort Study ‐ Dominance of the ε2 allele ?
Author(s) -
BOHNET K.,
REGISBAILLY A.,
VINCENTVIRY M.,
SCHLENCK A.,
GUEGUEN R.,
SIEST G.,
VISVIKIS S.
Publication year - 1996
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1996.tb01617.x
Subject(s) - allele , apolipoprotein e , genotype , genetics , dominance (genetics) , biology , apolipoprotein b , medicine , cholesterol , endocrinology , gene , disease
Summary Apolipoprotein (apo) E has been discussed as a marker for cardiovascular risk, but information about lipid traits in healthy individuals having one of the rare apoE genotypes (ε4/ε2, ε2/ε2 or ε4/ε4) is scarce. Our work was designed to answer the following questions: 1. Are the allelic effects of ε2 and ε4 on lipid traits additive or dominant? 2. If there is additivity, do the allelic effects of ε2 and ε4 have the same magnitude? 3. Are the allelic effects neutralised in ε4/ε2 individuals who are under the influence of both rare alleles? Allelic effects on apoB and apoE serum levels were codominant. Allelic models are thus not adequate to study the influence of apoE polymorphism on these traits. Allelic effects were additive for total cholesterol, LDL‐C, HDL‐C and apoAI, with ε2 having a greater impact than ε4. Serum levels differed significantly between ε4/ε2 and ε3/ε3 individuals only for apoE (p < 0ε001) and for apoB (p < 0ε05).