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Determining approximate estimates of inheritance parameters from sib‐pair IBD proportions
Author(s) -
GREEN J. R.,
SHAH S.
Publication year - 1996
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1996.tb01186.x
Subject(s) - inheritance (genetic algorithm) , genetics , haplotype , biology , neglect , statistics , mathematics , gene , allele , medicine , nursing
Summary The use of IBD proportions from a large set of affected sib‐pair data to estimate some or all of the main parameters describing the inheritance of a disease susceptibility gene is here considered. We assume there is no recombination present and neglect ascertainment bias, and assume that there are four distinct parental haplotypes present in each family.