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Exclusion from proximal 11q of a common gene with megaphenic effect on atopy
Author(s) -
WATSON M.,
LAWRENCE S.,
COLLINS A.,
BEASLEY R.,
DOULL I.,
BEGISHVILI B.,
LAMPE F.,
HOLGATE S. T.,
MORTON N. E.
Publication year - 1995
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1995.tb00759.x
Subject(s) - atopy , genetics , genetic linkage , candidate gene , locus (genetics) , biology , linkage (software) , gene , major gene , gene mapping , chromosome , immunology , allergy
SUMMARY We have typed three markers on proximal 11q in 131 random families with three or more children studied for atopy. A summary map that includes the FCER1B candidate was constructed. Using a 2‐locus disease model, we performed combined segregation and linkage analysis of three models, none of which suggested linkage. Nine marker loci on other chromosomes were also negative. In the regions swept by these 12 markers we cannot rule out a rare gene, perhaps of large effect, nor a common gene of small effect. However, a common gene of large effect is excluded. These results and alternative strategies are discussed in the perspective of inconsistent evidence for a major atopy gene.