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Lack of RH C/E expression in the Rhesus D– phenotype is the result of a gene deletion
Author(s) -
BLUNT T.,
STEERS F.,
DANIELS G.,
CARRITT B.
Publication year - 1994
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1994.tb00722.x
Subject(s) - gene , phenotype , rh blood group system , genetics , microbiology and biotechnology , biology , haplotype , homologous chromosome , allele , antibody
SUMMARY We have investigated the arrangement of genes in the rare Rh (Rhesus) partial null condition D–, Southern blot and PCR studies under conditions which distinguish the highly homologous RH D and RH C/E genes show that in an Icelandic family with the D– haplotype at least 85% of the RH C/E gene is deleted. This finding is in contrast to one other published case of this phenotype, where intact RH D and C/E genes were found, and also to the full amorph Rh null phenotype, where an intact RH C/E gene was found, accompanied by the deletion of the RH D gene typical of Rh D‐negative individuals.