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Mapping of RXRB to human chromosome 6p21. 3
Author(s) -
FITZGIBBON J.,
GILLETT G. T.,
WOODWARD K. J.,
BOYLE J. M.,
WOLFE J.,
POVEY S.
Publication year - 1993
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1993.tb01596.x
Subject(s) - biology , retinoid x receptor , genetics , fluorescence in situ hybridization , retinoid , retinoic acid , chromosome , microbiology and biotechnology , gene , somatic cell , nuclear receptor , transcription factor
Summary Retinoid X Receptor beta (RXRB) is a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). We have confirmed the localization of RXRB to chromosome 6 and we have mapped the gene to chromosome 6p21. 3‐p21.1 by PCR amplification of 5′ untranslated sequence in panels of rodent‐human somatic cell hybrids and to 6p21.3 by fluorescent in situ hybridization.