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Regional localization of the lactase‐phlorizin hydrolase gene, LCT, to chromosome 2q21
Author(s) -
HARVEY C. B.,
FOX M. F.,
JEGGO P. A.,
MANTEI N.,
POVEY S.,
SWALLOW D. M.
Publication year - 1993
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1993.tb01593.x
Subject(s) - lactase , gene , chromosome , biology , lactose intolerance , genetics , endocrinology , medicine , enzyme , lactose , biochemistry
Summary The gene LCT which codes for the intestinal disaccharidase lactase‐phlorizin hydrolase has previously been mapped, using somatic cell hybrids and linkage analysis, using the CEPH families, to chromosome 2. We describe here the regional localization of LCT to chromosome 2q21 by polymerase chain reaction (PCR) analysis of somatic cell hybrids and in situ hybridization. LCT is closely linked to D2844, with a lod score of 30.6 at θ= 0.10.