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Power comparison of various sibship tests of association
Author(s) -
GREEN J. R.,
SHAH S.
Publication year - 1993
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1993.tb00896.x
Subject(s) - association test , association (psychology) , locus (genetics) , genetic association , statistics , biology , genetics , mathematics , psychology , single nucleotide polymorphism , gene , genotype , psychotherapist
Summary There are several tests available for use with family studies to test if there is significant evidence of association with a particular disease gene locus, especially of HLA. We have used large simulations to compare the powers of tests using criteria N, R, T, PR, WP and some new tests involving both affecteds and unaffecteds in a sibship. It was found that tests using both affected and unaffected siblings were often more powerful.