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Complex polymorphisms are revealed by Y chromosome probe 49a with Bgl II, Hin dIII, Pst I and Sst I
Author(s) -
SPURDLE A. B.,
JENKINS T.
Publication year - 1993
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1993.tb00885.x
Subject(s) - haplotype , genetics , bglii , biology , population , psti , hindiii , bantu languages , restriction fragment length polymorphism , restriction enzyme , genotype , gene , demography , linguistics , philosophy , sociology
Summary Y chromosome probe 49a detects complex polymorphisms with Bgl II, Hin dIII, Pst I and Sst I, involving 19, 13, 18 and 11 variant bands respectively. The haplotype, a description of the arrangement of fragments in an individual, exhibits great variation. Most haplotypes are population‐specific and occur infrequently. In a study of approximately 60 individuals of Caucasoid, Negroid and San origin, 21, 23, 28 and 24 haplotypes were revealed by Bgl II, Hin dIII, Pst I and Sst I respectively. Reduced genetic diversity in the Negroid population was ascribed to both the proposed recent common origin of the Bantu‐speaking Negroid population from a proto‐Bantu stock and the common practice of polygamy in African Negroids, as were specific correlations between the different polymorphisms within the Negroid population only. In general, no single haplotype for a given enzyme system strictly correlated with a haplotype from any of the other three systems, suggesting that each polymorphism results from a combination of restriction site mutations and rearrangement events. This tremendous variability has potential in paternity testing for male offspring.