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Hazard and probabilities of unknown genotypes
Author(s) -
JEANPIERRE M.
Publication year - 1992
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1992.tb01160.x
Subject(s) - genotype , hazard , statistics , hazard ratio , set (abstract data type) , interpretation (philosophy) , econometrics , genetics , biology , mathematics , computer science , gene , ecology , confidence interval , programming language
Summary The likelihood of a genotype of an unsampled individual depends upon genetic data from relatives. When these relatives may be carriers of a mutation as in X‐linked disease, the likelihood of a genotype is altered by the consequences of the possible genotypes on offspring. The probabilities of the possible genotypes are easily derived from the probabilities conditional on the genotype obtained from a computer program aimed at risk calculation. This procedure of genotype reconstruction brings to light a potential hazard in the interpretation of computer data: a compound risk may be better represented as the harmonic mean of a set of conditional probabilities than the simple average of these probabilities.