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Regional localization of the intestinal mucin gene MUC3 to chromosome 7q22
Author(s) -
FOX M. F.,
LAHBIB F.,
PRATT W.,
ATTWOOD J.,
GUM J.,
KIM Y.,
SWALLOW D. M.
Publication year - 1992
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1992.tb01154.x
Subject(s) - genetics , chromosome , biology , mucin , gene , genetic linkage , linkage (software) , gene mapping , microbiology and biotechnology , biochemistry
Summary The gene MUC3 which codes for a mucin expressed in intestine (Gum et al. 1990) has previously been mapped, using somatic cell hybrids, to chromosome 7. We describe here the regional localization of MUC3 to chromosome 7q22 by in situ hybridization. Preliminary linkage analysis using CEPH (Centre d'Étude du Polymorphisme Humain) families supports this assignment and places MUC3 in the same linkage group as COL1A2 and CFTR.