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Dominant genes for colorectal cancer are not rare
Author(s) -
HOULSTON R. S.,
COLLINS A.,
SLACK J.,
MORTON N. E.
Publication year - 1992
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1992.tb01136.x
Subject(s) - colorectal cancer , gene , genetics , biology , medicine , cancer
Summary The genetic basis for colorectal cancer was investigated by complex segregation analysis of a published series of consecutive pedigrees ascertained through patients undergoing treatment for colorectal cancer. Analysis favoured a dominant gene or genes with a frequency of 0·006 with a lifetime penetrance of 0·63. These genes account for 81% of colorectal cancer in patients under 35, however, by 65 about 85% are phenocopies.