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The assignment of the genes coding for human complement components C6 and C7 to chromosome 5
Author(s) -
JEREMIAH S. J.,
ABBOTT C. M.,
MURAD Z.,
POVEY S.,
THOMAS H. J.,
SOLOMON E.,
DiSCIPIO R. G.,
FEY G. H.
Publication year - 1990
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1990.tb00370.x
Subject(s) - biology , gene , complementary dna , southern blot , genetics , microbiology and biotechnology , dna , polymerase chain reaction , coding region , chromosome , human genome , complement (music) , restriction enzyme , genome , phenotype , complementation
SUMMARY A panel of 19 somatic cell hybrids was tested for the presence of human sequences coding for complement components C6 and C7 by restriction enzyme digestion and Southern blots probed with human C6 and C7 cDNA probes. C7 was also detected by amplifying part of the human gene in hybrid DNA using the polymerase chain reaction. Detection of human C6 and C7 was completely correlated with the presence of chromosome 5.