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Analysing rearrangement breakpoint distributions by means of binomial confidence intervals
Author(s) -
VASARHELYI K.,
FRIEDMAN J.M.
Publication year - 1989
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1989.tb01805.x
Subject(s) - breakpoint , confidence interval , binomial proportion confidence interval , mathematics , randomness , binomial (polynomial) , statistics , binomial distribution , negative binomial distribution , chromosome , biology , genetics , poisson distribution , gene
SUMMARY Non‐randomness in the distribution of rearrangement breakpoints can be assessed by means of a binomial probability model. Using the binomial model, we compute confidence intervals for the observed number of breakpoints in chromosome bands and use these confidence intervals to test for non‐randomness in set of 452 constitutional rearrangement breakpoints. This method is useful because it describes the observed data and is not dependent on comparison with a pre‐existing hypothesis regarding the distribution.