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Recursive descent probabilities for rare recessive lethals
Author(s) -
THOMPSON E.A.,
MORGAN K.
Publication year - 1989
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1989.tb01804.x
Subject(s) - descent (aeronautics) , identity by descent , genetics , biology , allele , set (abstract data type) , trait , ancestor , rare events , gene , computer science , mathematics , statistics , haplotype , history , archaeology , engineering , programming language , aerospace engineering
SUMMARY Recursively computed descent probabilities provide an effective way to evaluate possible ancestries of rare alleles segregating in large and complex genealogies, but they ignore information other than the descent to a small set of current gene copies. We show how descent probability computations can be modified to incorporate the fact that no ancestor can be affected by a lethal recessive trait. This methodology is applied to two rare recessive traits segregating in a complex Hutterite (Lehrerleut) genealogy.