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Molecular characterization of human X/Y translocations suggests their aetiology through aberrant exchange between homologous sequences on Xp and Yq
Author(s) -
Ballabio A.,
Carrozzo R.,
Gil A.,
Gillard B.,
Affara N.,
FfergusonSmith M. A.,
Fraser N.,
Craig I.,
Rocchi M.,
Romeo G.,
Andria G.
Publication year - 1989
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1989.tb01117.x
Subject(s) - chromosomal translocation , biology , genetics , homologous chromosome , homology (biology) , y chromosome , chromosome , microbiology and biotechnology , gene
Summary Several DNA sequences from two homologous regions, localized on the distal part of the human X chromosome short arm and on the long arm of the Y chromosome, have been hybridized to DNAs from seven human‐rodent hybrids containing human X; Y translocation chromosomes. Molecular characterization of the translocated chromosomes has revealed, in all but one case, transfer of the Y cluster of sequences and complete deletion of the corresponding X‐chromosomal sequences. The possible role of X/Y homology in the aetiology of X; Y translocations is proposed.