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Multipoint mapping and the emperor's clothes
Author(s) -
MORTON N. E.
Publication year - 1988
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1988.tb01110.x
Subject(s) - pairwise comparison , linkage (software) , distortion (music) , computer science , gene mapping , genetics , pattern recognition (psychology) , algorithm , biology , artificial intelligence , gene , chromosome , amplifier , computer network , bandwidth (computing)
Summary On the hypothesis of no interference, pedigree probabilities for segregating loci considered simultaneously factor into pairwise probabilities, and multipoint mapping reduces to multiple pairwise mapping. Under these conditions, use of a computer program such as linkage or mapmaker entails no gain but substantial loss (measured as map distortion, wasted data, concealed evidence, redundant calculation and exaggerated multiple recombination) by comparison with maps based on lod scores. This is illustrated by the current maps of chromosomes 1 and 2.