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Detection of linkage between a quantitative trait and a marker locus by the lod score method: sample size and sampling considerations
Author(s) -
DEMENAIS F.,
LATHROP G. M.,
LALOUEL J. M.
Publication year - 1988
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1988.tb01101.x
Subject(s) - quantitative trait locus , locus (genetics) , recombination fraction , trait , sample size determination , linkage (software) , genetic linkage , statistics , lod score , genetics , biology , mathematics , computer science , gene mapping , gene , chromosome , programming language
Summary A simulation study is here conducted to measure the power of the lod score method to detect linkage between a quantitative trait and a marker locus in various situations. The number of families necessary to detect such linkage with 80% power is assessed for different sets of parameters at the trait locus and different values of the recombination fraction. The effects of varying the mode of sampling families and the sibship size are also evaluated.