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The major phenobarbital‐inducible cytochrome P‐450 gene subfamily (P450IIB) mapped to the long arm of human chromosome 19
Author(s) -
SANTISTEBAN I.,
POVEY S.,
SHEPHARD E. A.,
PHILLIPS I. R.
Publication year - 1988
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1988.tb01088.x
Subject(s) - subfamily , biology , locus (genetics) , complementary dna , gene , genetics , microbiology and biotechnology , southern blot , chromosome , gene mapping , chromosome 22
Summary We have recently isolated a cloned cDNA that codes for a human orthologue of the major phenobarbital‐inducible cytochrome P450IIB subfamily of rodents. The cloned human cDNA was used to analyse, by Southern blot hybridization, DNA extracted from a panel of 9 independent human‐rodent somatic cell hybrids. The results indicate that all members of the P450IIB gene subfamily of man are located on chromosome 19. Evidence from hybrids containing different regions of human chromosome 19 localizes this cytochrome P‐450 gene subfamily further to the long arm of chromosome 19 in the region cen‐q13.3. We propose the designation CYP2B for this locus.