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The assignment of the human gene coding for complement C5 to chromosome 9q22‐9q33.
Author(s) -
JEREMIAH S. J.,
WEST L. F.,
DAVIS M.,
POVEY S.,
CARRITT B.,
FEY G. H.
Publication year - 1988
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1988.tb01085.x
Subject(s) - biology , gene , genetics , microbiology and biotechnology , chromosome , chromosome 9 , complementary dna , clone (java method) , gene mapping
Summary The presence or absence of the human gene for the fifth component of complement (C5) was analysed in 19 human‐rodent hybrid cell lines by hybridization to a radiolabelled probe derived from a human C5 cDNA clone. The segregation of C5 in these hybrids suggested that the gene is localized on chromosome 9, in the region 9q21‐9qter. In situ hybridization refined the assignment of C5 to chromosome 9q22‐33.