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Regional assignment of the gene coding for human sucrase‐isomaltase ( SI ) to chromosome 3q25‐26
Author(s) -
WEST L. F.,
DAVIS M. B.,
GREEN F. R.,
LINDENBAUM R. H.,
SWALLOW D. M.
Publication year - 1988
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1988.tb01077.x
Subject(s) - biology , genetics , gene , chromosome , complementary dna , chromosomal translocation , gene mapping , microbiology and biotechnology , metaphase
Summary The gene coding for sucrase‐isomaltase ( SI ) has recently been mapped to chromosome 3 using a cDNA probe to analyse DNA from somatic cell hybrids (Green et al. 1987). We have now used this same cDNA probe to obtain a regional localization of this gene. In situ hybridization to normal metaphase chromosomes and to chromosomes from individuals with balanced translocations suggests a regional assignment to chromosome 3q25‐26.