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Localization of the oncogene c‐ erb A2 to human chromosome 3
Author(s) -
RIDER S. H.,
GORMAN P. A.,
SHIPLEY J. M.,
MOORE G.,
VENNSTROM B.,
SOLOMON E.,
SHEER D.
Publication year - 1987
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1987.tb01057.x
Subject(s) - chromosome 22 , biology , chromosome , metaphase , genetics , chromosome 21 , somatic cell , chromosome 17 (human) , chromosome 7 (human) , chromosome 3 , human genome , chromosome 19 , microbiology and biotechnology , gene , genome
Summary The human c‐ erb Al gene has been previously mapped to chromosome 17. We have now mapped c‐ erb A2 to the short arm of chromosome 3, using a human genomic probe in Southern analysis of DNA from a panel of human/mouse somatic cell hybrids. In situ hybridization using the same probe on metaphase chromosomes has enabled fine chromosome mapping of c‐ erb A2 to the chromosome region 3p21‐pter.