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Very close linkage between D2S1 and ACP1 on chromosome 2p
Author(s) -
LOTHE R. A.,
GEDDEDAHL T.,
OLAISEN B.,
BAKKERS E.,
PEARSON P.
Publication year - 1986
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1986.tb01757.x
Subject(s) - bglii , genetics , recombination fraction , biology , recombination , genetic linkage , allele , restriction fragment length polymorphism , linkage (software) , gene , chromosome , microbiology and biotechnology , genotype , gene mapping , restriction enzyme , ecori
Summary The genomic DNA‐probe L2.30 was used to assign D2S1 to 2p23–pter by in situ hybridization. The RFLP revealed by Bgl II was then used for linkage studies in the Oslo‐NHIK families segregating for the acid phosphatase ACPl protein polymorphism. Evidence for very close linkage was found by a lod score of +17.17 at recombination fraction θ = 001. By this close linkage 92 informative meioses could be inferred from the families and with only a single crossover. The upper probability limit to the recombination fraction is 006 according to the HGM 8 criterion. No association between ACP1 alleles and D2S1 Bgl II alleles was found. The Norwegian gene frequencies for 0251 were A1 (9–0 kb) = 065 and A2 (6.3 kb) = 0.35.