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Inherited electrophoretic variants detected in a Japanese population with two‐dimensional gels of erythrocyte lysates
Author(s) -
TAKAHASHI N.,
NEEL J. V.,
NAGAHATASHIMOICHI Y.,
ASAKAWA J.,
TANAKA Y.,
SATOH C.
Publication year - 1986
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1986.tb01753.x
Subject(s) - genetics , inheritance (genetic algorithm) , biology , allele , polyacrylamide gel electrophoresis , genetic variation , electrophoresis , genetic variants , polymorphism (computer science) , population , allele frequency , microbiology and biotechnology , gene , genotype , biochemistry , medicine , environmental health , enzyme
Summary Genetic variation has been studied in erythrocyte lysates from 100 Japanese children and their parents by means of two‐dimensional polyacrylamide gel electrophoresis. Fifty‐five polypeptides selected without respect to variability were considered suitable for scoring. Genetic variation was encountered in 14 of these polypeptides. Family data show that the segregation of 13 variants is consistent with an autosomal codominant mode of inheritance; the remaining variant exhibits a sex‐linked mode of inheritance. Of 8 presumably identical polypeptides found variable in Japanese and/or Caucasians, differences in the occurrence or allele frequencies of polymorphisms were recognized for four. Contrary to the experience of some investigators, the amount of variation and the ethnic differences we are encountering indicate that two‐dimensional polyacrylamide gel electrophoresis is a sensitive tool for the study of genetic events.