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The human type II collagen gene ( COL2A1 ) assigned to 12q14.3
Author(s) -
LAW M. L.,
TUNG L.,
MORSE H. G.,
BERGER R.,
JONES C.,
CHEAH K.S.E.,
SOLOMON E.
Publication year - 1986
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1111/j.1469-1809.1986.tb01031.x
Subject(s) - gene , biology , cosmid , somatic cell , genetics , chromosome , clone (java method) , microbiology and biotechnology , hybrid , botany
Summary A cosmid clone containing the entire human type II α1 collagen gene ( COL2A1 ) was used as probe in the Southern analysis of DNA from a panel of human/hamster somatic cell hybrids containing different portions of human chromosome 12. Two of the hybrids exhibited a similar terminal deletion q14.3→qter, but one was positive for the gene while the other was negative. Therefore, the gene must reside in the region q14.3.